Long-acting liposomal corneal anesthetics

RELATIONSHIPS BETWEEN LIPOPHILIC CHARACTER AND BIOLOGICAL ACTIVITY OF NEW POTENTIAL LONG-ACTING LOCAL ANESTHETICS

The partition coefficients (P-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. These are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. Their aqueous solutions have shown different absorption maxima, and these have been use...

relationships between lipophilic character and biological activity of new potential long-acting local anesthetics

the partition coefficients (p-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. these are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. their aqueous solutions have shown different absorption maxima, and these have been used qu...

Long-acting sulfonylureas -- long-acting hypoglycaemia.

Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine.

Levobupivacaine and ropivacaine, two new long-acting local anesthetics, have been developed as an alternative to bupivacaine, after the evidence of its severe toxicity. Both of these agents are pure left-isomers and, due to their three-dimensional structure, seem to have less toxic effects on the central nervous system and on the cardiovascular system. Many clinical studies have investigated th...

Relationships between Lipophilic Character and Biological Activity of New Potential Long-acting Local Anesthetics

The partition coefficients (P-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanoV phosphate buffer system. These are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. Their aqueous solutions have shown different absorption maxima, and these have been used qua...